Characterization of the benzodiazepine binding site (diazepam site) on human serum albumin.

Investigating Dynamic Properties of Residues of Warfarin-Azapropazone Binding Site in Human Serum Albumin

Introduction: Human Serum Albumin (HSA) is one of the most important proteins in blood that can bind a wide range of components and different drugs such as Warfarin and is also circulated in the body by HSA. Therefore, studying HSA is very significant in pharmacology. In this research, dynamic behavior of residues of Warfain binding site of HSA has been investigated. Methods: Firstly, PDB form...

Investigating Dynamic Properties of Residues of Warfarin-Azapropazone Binding Site in Human Serum Albumin

Introduction: Human Serum Albumin (HSA) is one of the most important proteins in blood that can bind a wide range of components and different drugs such as Warfarin and is also circulated in the body by HSA. Therefore, studying HSA is very significant in pharmacology. In this research, dynamic behavior of residues of Warfain binding site of HSA has been investigated. Methods: Firstly, PDB form...

bioinformatics analysis of human serum albumin for determination of herbal anti-diabetic compound binding site

Carboxylate Forms of Camptothecins -CPT, SN22 and Karenitecin® Bind Specifically to Site II (Diazepam site) of Human Serum Albumin

Camptothecins are an important class of anti-cancer agents and under physiological conditions exist in equilibrium between the lactone and carboxylate forms. The lactone form of camptothecins is crucial for their anti-tumor effect. Camptothecins, especially carboxylate forms, bind strongly to the plasma protein, human serum albumin (HSA). This binding of the carboxylate form alters the hydrolys...

The Investigation of the Binding of 6-Mercaptopurine to Site I on Human Serum Albumin

6-Mercaptopurine (6-MP) is one of a large series of purine analogues which has been found active against human leukemias. The equilibrium dialysis, circular dichroism (CD) and molecular docking were employed to study the binding of 6-MP to human serum albumin (HSA). The binding of 6-MP to HSA in the equilibrium dialysis experiment was detected by measuring the displacement of 6-MP by specific m...